陈小川
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陈小川,生于1984年,博士,副教授,研究生导师。

 

1. 受教育经历

2009/06–2012/05 美国亚利桑那大学,博士

2007/08–2009/05 美国亚利桑那大学,硕士

2003/09– 2007/06,中国西南大学,学士

 

2. 研究工作经历

2013/01–至今,西南大学,动物科技学院,副教授,研究生导师

2012/10–2012/12,西南大学,动物科技学院,讲师

 

3. 研究兴趣与方向

主要采用动物胎儿模型,致力于子宫内环境对胎儿后期发育及后天生长过程中的内分泌和代谢调控研究。

1)     母体低营养对胎儿在子宫内发育及其后天生长的影响。

2)     环境热应激对胎儿和新生儿胰腺内分泌的调控研究。

先后主持了西南大学博士基金和中央高校基本科研业务费各1项;曾主要参与了美国NIH R01-DK-084842NIH T32-HL-7249NIH F32-DK-088514USDA 2012-67012-19855等项目;并与美国亚利桑那大学(The University of Arizona)拥有非常深层次的交流与合作担任动物科技学院《生物化学》和《分子生物学》本科教学。。

 

4. 期刊论文(通讯作者以“*”标出)

曾在《American Journal of Physiology Endocrinology and Metabolism》(2013年生理学类Top 7),《Journal of Physiology》(2013年生理学类Top 8)等国际一流生理学期刊和国际会议上发表论文10余篇,第一作者3篇,并编写英文教材1部。

1) Chen X (陈小川), Green AS, Macko AR, Yates DT, Kelly AC, Limesand SW*. Enhanced insulin secretion responsiveness and islet adrenergic desensitization after chronic norepinephrine suppression is discontinued in fetal sheep. Am J Physiol Endocrinol Metab. 2014 Jan 1;306(1):E58-64. doi: 10.1152/ajpendo.00517. (2014, IF = 4.514). 

2) Macko AR, Yates DT, Chen X, Green AS, Kelly AC, Brown LD, Limesand SW*. Elevated plasma norepinephrine inhibits insulin secretion, but adrenergic blockade reveals enhanced β-cell responsiveness in an ovine model of placental insufficiency at 0.7 of gestation. J Dev Orig Health Dis. 2013 Oct 1;4(5). (2013, IF = 1.207). 

3) Yates DT, Macko AR, Chen X, Green AS, Kelly AC, Anderson MJ, Fowden AL, Limesand SW*. Hypoxaemia-induced catecholamine secretion from adrenal chromaffin cells inhibits glucose-stimulated hyperinsulinaemia in fetal sheep. The Journal of Physiology. 590(Pt 21):5439-47. (2012, IF = 4.38). 

4) Yates DT, Macko AR, Nearing M, Chen X, Rhoads RP, Limesand SW*. Developmental programming in response to intrauterine growth restriction impairs myoblast function and skeletal muscle metabolism. Journal of Pregnancy. 2012:631038. (2012). 

5) Chen X, Rozance PJ, Hay WW Jr, Limesand SW*. Insulin-like Growth Factor and Fibroblast Growth Factor Expression Profiles in Growth Restricted Fetal Sheep Pancreas. Experimental Biology and Medicine (Maywood). 237(5):524-9. (2012, IF = 2.803). 

6) Green AS, Chen X, Macko AR, Anderson MJ, Kelly AC, Hart NJ, Lynch RM, Limesand SW*. Chronic Pulsatile Hyperglycemia Reduces Insulin Secretion and Increases Accumulation of Reactive Oxygen Species in Fetal Sheep Islets. The Journal of Endocrinology. 212(3):327-42. (2011, IF = 4.746). 

7) Green AS, Macko AR, Rozance PJ, Yates DT, Chen X (陈小川), Hay WW Jr, Limesand SW*. Characterization of glucose-insulin responsiveness and impact of fetal number and gender on insulin response in the sheep fetus. American Journal of Physiology Endocrinology and Metabolism. 300(5), E817-823. (2011, IF = 4.746). 

8) Chen X, Fahy AL, Green AS, Anderson MJ, Rhoads Jr RP, Limesand SW*. β2-Adrenergic Receptor Desensitization in Perirenal Adipose Tissue in Fetuses and Lambs with Placental Insufficiency-induced Intrauterine Growth Restriction. The Journal of Physiology. 588(Pt 18):3539-49. (2010, IF = 5.139). 

9) Leos RA, Anderson MJ, Chen X, Pugmire J, Anderson KA, Limesand SW*. Chronic exposure to elevated norepinephrine suppresses insulin secretion in fetal sheep with placental insufficiency and intrauterine growth restriction. American Journal of Physiology Endocrinology and Metabolism. 298, E770-778. (2010, IF = 4.686). 

 

5. 会议论文(通讯作者以“*”标出)

1) Chen X, Green AS, Macko AR, Anderson MJ, Zehri A, and Limesand SW*. Chronic norepinephrine infusion suppresses insulin secretion but once removed, leads to enhanced insulin secretion in the fetal sheep. Diabetes 70th Scientific Session. Abstract 2496-PO. Orlando, Florida, USA. (2010).

2) Chen X, Macko AR., Green AS, Yates DT, Anderson MJ, Kelly AC, Zehri A, and Limesand SW*. Enhanced Insulin Secretion in the Fetal Sheep after Chronic Norepinephrine Infusion Suppression. Society for Gynecologic Investigation 2011 Annual Meeting. 18(4):F-116. Miami, Florida, USA. (2011).

3) Chen X, Yates DT, Macko AR, Kelly AC, and Limesand SW*. Chronic Norepinephrine Exposure Desensitizes Fetal Sheep Islets and Enhances Insulin Secretion. Society for Gynecologic Investigation 2012 Annual Meeting. 19(3):T-088. San Diego, California, USA. (2012).

 

6. 专著

1) Yates DT, Chen X, Limesand SW. Environmental Physiology of Livestock. (Environmental Heat Stress Impairs Placental Function, Fetal Growth and Development, and Postnatal Performance in Livestock). Wiley-Blackwell by John Wiley &. Sons, Inc. ISBN-13: 978-0-8138-1176-5. 368 pages. (2012).

 

7. 获奖情况

陈小川,重庆市引进高层次人才(第四类),2013

陈小川,美国亚利桑那大学E. Ray Cowden 奖学金,2007-2012

 

8. 研究生招生

[1] 基础兽医学(专业代码:090601);研究方向:动物生理学(代码:02

 

9. 实验室组员2013 至今)

李妍蓥,2012级动物科学本科在读,主要实验方向:RT-PCR & Real-time PCR

牟烨,2012级动物科学本科在读,主要实验方向:组织切片及免疫荧光染色

汤琦,2012级动物科学本科在读,主要实验方向:Total RNA的提取和实验室管理

王小巧,2012级动物科学本科在读,主要实验方向:大鼠胰岛细胞提取和细胞培养

 

联系地址:重庆市北碚区西南大学动物科技学院30教学楼207

邮编:400715

E-mail: drfrankthetank@gmail.com

Weibo: http://weibo.com/u/3835807220



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